Beyer, John L., Cassidy, Frederick,Kuchibhatla, MacFall, James ,Maragatha , Payne, Martha E. Ranga, K.Krishnan, R . Gray and white matter brain volumes in older adults with bipolar disorder.International Journal of Geriatric Psychiatry; Dec2009, Vol. 24 Issue 12, p1445-1452, 8p,
The article I chose is looking at gray and white matter volumes in older patients with bipolar disorder. The study consisted of fifty six adults with the mean age 60.5 and forty three normal controls. The researchers conducted MRI scans and divided the cerebrum into 16 units. The volumetric differences were examined using the multivariate linear regression models. The researchers results fund that compared to healthy controls , older adults with bipolar disorder did not have significant differences in total white and gray matter. Using parcellation techniques, the researchers found in older adults with bipolar disorder there were significantly smaller gray matter volumes bilaterally in the inferior frontal areas. White matter volume was also reduced in these same areas but there was not a statistical significance when looking at gender and age. The researcher’s findings showed older adults with bipolar disorder showed gray matter volumetric deficits inferior frontal lobe regions. These areas play an active role in the mood and cognitive symptoms of bipolar disorder. The findings of this study may suggest that gray matter volume loss may accelerate in certain regions of bipolar subjects as they age. Further research in these areas could help aid in the treatment of bipolar disorder and its effect on the cognitive function of bipolar patients.
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